Layout and Design of Cleanrooms Across Different Industries

No. 8 Songmu East Road, Hongsha Industrial Park Community, Shishan，Nanhai，Foshan，Guangdong，China +86-18379778096 [email protected] No. 8 Songmu East Road, Hongsha Industrial Park Community, Shishan，Nanhai，Foshan，Guangdong，China Home >  News & Event >  Company News Cleanrooms must be divided into clean zones, semi-clean zones, and auxiliary areas. Functional zones should be independent and physically isolated. Process flows must follow unidirectional principles to avoid cross-contamination between personnel and materials. Core clean areas should be located at the center or upwind side of the building to minimize external interference. Unidirectional Flow Cleanrooms: Use vertical laminar flow or horizontal laminar flow with an airflow velocity of 0.3–0.5 m/s. Suitable for high-cleanliness scenarios such as semiconductors and biopharmaceuticals. Non-Unidirectional Flow Cleanrooms: Maintain cleanliness through high-efficiency filtration and dilution, with air change rates of 15–60 times per hour. Suitable for medium-to-low cleanliness scenarios such as food and cosmetics. Mixed Flow Cleanrooms: Combine unidirectional flow in core areas with non-unidirectional flow in peripheral areas to balance cost and efficiency. The pressure difference between clean and non-clean areas should be ≥5 Pa, and between clean areas and the outdoors ≥10 Pa. Adjacent clean areas should have a reasonable pressure gradient, with higher-pressure zones in higher-cleanliness areas. Core process areas (e.g., photolithography, etching) must meet ISO 14644-1 Class 1 or Class 10, with particle concentrations ≤3,520 particles/m³ (0.5 μm). Auxiliary areas may have relaxed cleanliness standards of ISO Class 7 or 8. Temperature: 22 ± 1°C, relative humidity: 40%–60%, maintained by constant temperature and humidity HVAC systems. Conductive epoxy flooring or anti-static PVC flooring with resistance ≤1 × 10⁶ Ω. Personnel must wear anti-static clothing and shoe covers; equipment grounding resistance ≤1 Ω. Core process areas are located at the building center, surrounded by equipment and testing rooms. Materials enter through airlocks; personnel enter through air showers. Exhaust systems are independent, with emissions filtered through HEPA before release. Aseptic filling areas must meet Grade A (ISO Class 5), with localized Class 100 conditions. Cell culture and bacterial operation areas must meet Grade B (ISO Class 6). Auxiliary areas (e.g., sterilization rooms, material storage) must meet Grade C (ISO Class 7) or Grade D (ISO Class 8). Experiments involving highly pathogenic microorganisms must be conducted in BSL-2 or BSL-3 laboratories with negative pressure, interlocked doors, and emergency shower equipment. Sterilization rooms must use fire-resistant, high-temperature-resistant materials and be equipped with steam sterilizers or hydrogen peroxide vaporizers. Bacterial and cell culture rooms are isolated and physically separated from clean filling areas. Materials enter via pass-through windows; personnel enter through changing rooms and buffer zones. Exhaust systems are equipped with HEPA filters and activated carbon adsorption units. Ready-to-eat food packaging areas must meet Class 100,000 (ISO Class 8), with particle concentrations ≤3.52 million/m³ (0.5 μm). Raw material handling and non-ready-to-eat food packaging areas must meet Class 300,000 (ISO Class 9). Temperature: 18–26°C, relative humidity ≤75% to prevent microbial growth from condensation. Clean operation areas (e.g., inner packaging) are located upwind; semi-clean areas (e.g., raw material handling) are downwind. Materials enter through buffer rooms; personnel enter through changing rooms and hand-sanitizing areas. Exhaust systems use primary and medium-efficiency filters, with regular filter replacements. Emulsification and filling rooms must meet Class 100,000 (ISO Class 8). Raw material storage and packaging areas must meet Class 300,000 (ISO Class 9). Walls use mildew-resistant paint or color steel plates; floors use epoxy self-leveling coatings with sealed seams. Lighting fixtures use sealed cleanroom lamps to prevent dust accumulation. Emulsification and filling rooms are isolated and equipped with localized Class 100 clean benches. Materials enter via pass-through windows; personnel enter through changing rooms and air showers. Exhaust systems use activated carbon adsorption to remove volatile organic compounds. Noise Control: Noise levels ≤65 dB(A), achieved using low-noise fans and silencers.
Lighting Design: Average illumination ≥500 lx, uniformity ≥0.7, using shadowless lamps or LED cleanroom lights.
Fresh Air Volume: ≥40 m³ per person per hour to compensate for exhaust and maintain positive pressure. HEPA filters replaced every 6–12 months; primary and medium-efficiency filters cleaned monthly. Floors and walls cleaned and disinfected weekly; equipment surfaces wiped daily. Regular testing for airborne microbes and suspended particles, with records maintained. Each cleanroom level must have ≥2 emergency exits; evacuation doors open in the direction of escape. Air showers must have bypass doors if occupancy exceeds 5 people. Clean areas use gas fire suppression systems (e.g., heptafluoropropane) to avoid water damage. Emergency lighting and evacuation signs must provide ≥30 minutes of backup power. Biosafety laboratories must have emergency evacuation routes and eyewash stations. Chemical storage areas must have spill containment trays and absorbent materials. Analysis of Challenges in Prefabricated Medical Cleanroom Construction Future Challenges in Cleanroom Technology: Semiconductor Chips, Pharmaceuticals, and Biotechnology Huaao clean technology group is a national high-tech enterprise that produces clean maintenance system materials. No. 8 Songmu East Road, Hongsha Industrial Park Community, Shishan，Nanhai，Foshan，Guangdong，China Copyright © Guangdong Huaao Clean Technology Group Co., Ltd All Rights Reserved